Autoimmune hepatitis
نویسنده
چکیده مقاله:
Autoimmune hepatitis is (AIH) is a chronic hepatitis that occurs in children and adults of all ages. It is characterized by immunologic and autoimmune features, including circulating auto antibodies and high serum globulin concentrations. It was first described in the 1950s by term of chronic active hepatitis. It has 2 types with different auto antibodies. Diagnosis is based upon serologic and histologic findings and exclusion of other forms of chronic liver disease. A scoring system should be used in assessment based upon: 1) Auto anti bodie titer 2) Serum IgG level 3) Liver histology 4) Absence of viral and other causes of hepatitis. Clear indications for treatment: 1) rise of aminotrasferases 2) clinical symptoms of liver disease 3) histological features in liver biopsy 4) Children with AIH initial treatment involve glucocorticoid with or without azathioprine. For patients with fulminant hepatitis liver transplantation, should be kept in mind. Remission is defined by: 1) Resolution of symptoms 2) Normalization of serum trasaminases 3) Normalization of serum bilirubin and gamma globuline levels. 4) Improvement in liver histology 5) Treatment is continued for at least 2-5 years, glucocorticoids are with drawn first, by tapering over six weeks. Azathioprine will be with drawn.
منابع مشابه
Autoimmune hepatitis.
N Engl J Med 2006;354:54-66. Copyright © 2006 Massachusetts Medical Society. A utoimmune hepatitis is a generally progressive, chronic hepatitis of unknown cause that occurs in children and adults of all ages. Occasionally, it has a fluctuating course, with periods of increased or decreased activity. The diagnosis is based on histologic abnormalities, characteristic clinical and biochemical fin...
متن کاملAutoimmune hepatitis.
Autoimmune hepatitis is an uncommon disease causing chronic inflammation of the liver and associated with various circulating autoantibodies. It shares some characteristics with other autoimmune liver diseases, such as primary biliary cirrhosis and sclerosing cholangitis. There has been confusion in past years regarding this entity, but there are now recognized diagnostic criteria by which to m...
متن کاملAutoimmune hepatitis.
Autoimmune hepatitis (AIH) is a rare disease, characterized by female predominance, hypergammaglobulinemia, autoantibodies, association with HLA DR3 and HLA DR4 and a good response to immunosuppression. Different subtypes of AIH may be distinguished, based on differences in the autoantibody patterns. AIH type 1 is characterized by anti-nuclear (ANA) and/or anti-smooth muscular (SMA) autoantibod...
متن کاملAutoimmune hepatitis.
Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specific autoantigens. It is characterized by female predilection, elevated aminotransferase levels, autoantibodies, increased γ-globulin or IgG levels and biopsy evidence of interface hepatitis. It is currently divided into types 1 and 2, based on expression of autoantibodies. Autoantigenic epi...
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عنوان ژورنال
دوره 2 شماره 2.1
صفحات 11- 11
تاریخ انتشار 2014-04-01
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